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Article

Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability.

RNA (New York, N.Y.) - 1 Oct 2013

Saguez Cyril, Gonzales Fernando A, Schmid Manfred, Bøggild Andreas, Latrick Chrysa M, Malagon Francisco, Putnam Andrea, Sanderson Lee, Jankowsky Eckhard, Brodersen Ditlev E, Jensen Torben Heick

Abstract excerpt

Sub2p/UAP56 is a highly conserved DEAD-box RNA helicase involved in the packaging and nuclear export of mRNA/protein particles (mRNPs). In Saccharomyces cerevisiae, Sub2p is recruited to active chromatin by the pentameric THO complex and incorporated into the larger transcription-export (TREX) complex. Sub2p also plays a role in the maintenance of genome integrity as its inactivation causes severe...

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Identifiers

PMID: 23962665
DOI: 10.1261/rna.040048.113
PMCID: PMC3854527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability.PMID 23962665Read ↗

The DECD box putative ATPase Sub2p is an early mRNA export factor.Semantic proximity Read ↗

THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.Semantic proximity Read ↗

DEAD-box RNA helicase Sub2 is required for expression of lacZ fusions in Saccharomyces cerevisiae and is a dosage-dependent suppressor of RLR1 (THO2).Semantic proximity Read ↗

Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation.Semantic proximity Read ↗

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.Semantic proximity Read ↗

Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.Semantic proximity Read ↗

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.Semantic proximity Read ↗

Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability.Semantic proximity Read ↗

Structural differences between the closely related RNA helicases, UAP56 and URH49 fashions distinct functional apo-complexesSemantic proximity Read ↗

Crystal structure of the human ATP-dependent splicing and export factor UAP56.Semantic proximity Read ↗

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.Semantic proximity Read ↗

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Semantic proximity Read ↗

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