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NMR Screen Reveals the Diverse Structural Landscape of a G-Quadruplex Library.

Chemistry (Weinheim an der Bergstrasse, Germany) - 2 Dec 2024

Sgallová Ráchel, Volek Martin, Kurfürst Jaroslav, Srb Pavel, Veverka Václav, Curtis Edward A

Abstract excerpt

G-quadruplexes are noncanonical nucleic acid structures formed by stacked guanosine tetrads. Despite their functional and structural diversity, a single consensus model is typically used to describe sequences with the potential to form G-quadruplex structures. We are interested in developing more specific sequence models for G-quadruplexes. In previous work, we functionally characterized each sequence in a...

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PMID: 39159147
DOI: 10.1002/chem.202401437
PMCID: PMC11610706

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