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Article

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.

Nucleic acids research - 1 Jan 2006

Dai Jixun, Chen Ding, Jones Roger A, Hurley Laurence H, Yang Danzhou

Abstract excerpt

BCL2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the P1 promoter plays an important role in the transcriptional regulation of BCL2. Here we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K+ solution. This well-defined...

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Identifiers

PMID: 16998187
DOI: 10.1093/nar/gkl610
PMCID: PMC1636422

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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