Diffusion-ordered nuclear magnetic resonance spectroscopy for analysis of DNA secondary structural elements.

doi:10.1016/j.ab.2007.04.025

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Article

Diffusion-ordered nuclear magnetic resonance spectroscopy for analysis of DNA secondary structural elements.

Analytical biochemistry - 1 Aug 2007

Ambrus Attila, Yang Danzhou

Abstract excerpt

Structure determination of secondary DNA structural elements, such as G-quadruplexes, gains an increasing importance as fundamental physiological roles are being associated with the formation of such structures in vivo. A truncated native DNA sequence generally requires further optimization to obtain a candidate with desired nuclear magnetic resonance (NMR) properties for structural analysis in solution. The...

Topics

Base Sequence
DNA
Diffusion
Genes, bcl-2
Genes, myc
Humans
Macromolecular Substances
Mutation
Nuclear Magnetic Resonance, Biomolecular
Nucleic Acid Conformation
Promoter Regions, Genetic
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Telomere

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Identifiers

PMID: 17570331
DOI: 10.1016/j.ab.2007.04.025
PMCID: PMC1993845

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