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Article

Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.

Biochemistry - 17 Mar 1998

Beckwith W H, Sun Q, Bosso R, Gerik K J, Burgers P M, McAlear M A

Abstract excerpt

Replication factor C (RFC) and the proliferating cell nuclear antigen (PCNA) are two essential DNA polymerase accessory proteins that are required for numerous aspects of DNA metabolism including DNA replication, DNA repair, and telomere metabolism. PCNA is a homotrimeric ring-shaped sliding DNA clamp that can facilitate DNA replication by tethering DNA polymerase delta or DNA polymerase epsilon to the DNA...

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Identifiers

PMID: 9521689
DOI: 10.1021/bi972777j

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.PMID 9521689Read ↗

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ATP utilization by yeast replication factor C. IV. RFC ATP-binding mutants show defects in DNA replication, DNA repair, and checkpoint regulation.Semantic proximity Read ↗

The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

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