Article
Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.
Biochemistry - 17 Mar 1998
Beckwith W H, Sun Q, Bosso R, Gerik K J, Burgers P M, McAlear M A
Abstract excerpt
Replication factor C (RFC) and the proliferating cell nuclear antigen (PCNA) are two essential DNA polymerase accessory proteins that are required for numerous aspects of DNA metabolism including DNA replication, DNA repair, and telomere metabolism. PCNA is a homotrimeric ring-shaped sliding DNA...
Topics
- Adenosine Triphosphate
- Alleles
- Amino Acid Sequence
- Carrier Proteins
- Cell Cycle Proteins
- DNA, Fungal
- Genes, Suppressor
- Hydrolysis
- Membrane Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Proliferating Cell Nuclear Antigen
- Protein Binding
- Replication Protein C
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins