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Article

Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.

The Journal of biological chemistry - 16 Oct 2009

Beamish Heather, de Boer Leonore, Giles Nichole, Stevens Frankie, Oakes Vanessa, Gabrielli Brian

Abstract excerpt

Mutations in adenomatous polyposis coli (APC) protein is a major contributor to tumor initiation and progression in several tumor types. These mutations affect APC function in the Wnt-beta-catenin signaling and influence mitotic spindle anchoring to the cell cortex and orientation. Here we report that the mitotic anchoring and orientation function of APC is regulated by cyclin A/cdk2. Knockdown of cyclin A and...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19703905
DOI: 10.1074/jbc.M109.042820
PMCID: PMC2781448

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.PMID 19703905Read ↗

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The tumor suppressor APC is an attenuator of spindle-pulling forces during <i>C. elegans</i> asymmetric cell divisionSemantic proximity Read ↗

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.Semantic proximity Read ↗

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Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progressionSemantic proximity Read ↗

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