Article
The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.
The EMBO journal - 15 Nov 1995
Baeg G H, Matsumine A, Kuroda T, Bhattacharjee R N, Miyashiro I, Toyoshima K, Akiyama T
Abstract excerpt
The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence junction protein catenin. Here we show that overexpression of APC blocks serum-induced cell cycle progression from G0/G1 to the S phase. Mutant APCs identified in FAP and/or colorectal tumours were less inhibitory and...
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