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Article

Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment.

Cell - 21 Feb 2003

Liakopoulos Dimitris, Kusch Justine, Grava Sandrine, Vogel Jackie, Barral Yves

Abstract excerpt

Spindle alignment is the process in which the two spindle poles are directed toward preselected and opposite cell ends. In budding yeast, the APC-related molecule Kar9 is required for proper alignment of the spindle with the mother-bud axis. We find that Kar9 localizes to the prospective daughter cell spindle pole. Kar9 is transferred from the pole to cytoplasmic microtubules, which are then guided in a...

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Source

Identifiers

PMID: 12600318
DOI: 10.1016/s0092-8674(03)00119-3

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment.PMID 12600318Read ↗

The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast.Semantic proximity Read ↗

The cyclin-dependent kinase Cdc28p regulates multiple aspects of Kar9p function in yeast.Semantic proximity Read ↗

Actin-mediated delivery of astral microtubules instructs Kar9p asymmetric loading to the bud-ward spindle pole.Semantic proximity Read ↗

The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p.Semantic proximity Read ↗

Stable preanaphase spindle positioning requires Bud6p and an apparent interaction between the spindle pole bodies and the neck.Semantic proximity Read ↗

Kar9 symmetry breaking alone is insufficient to ensure spindle alignment.Semantic proximity Read ↗

Differential contribution of Bud6p and Kar9p to microtubule capture and spindle orientation in S. cerevisiae.Semantic proximity Read ↗

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