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Article

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

2020-12-22

Abstract excerpt

Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating β-catenin target genes. Recent evidence showed that β-catenin-independent Wnt signaling is also required for faithful execution of mitosis. This mitotic Wnt signaling functions through Wnt-dependent stabilization of proteins (Wnt/STOP), as well as through components of the LRP6 signalosome. However, the targets and specifi...

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Identifiers and source

Literature Corpus work
b6a0cf8b-1cec-5748-831e-eea5eabf78ba
DOI
10.1101/2020.12.22.404020
Open publication

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Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosisDOI 10.1101/2020.12.22.404020
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