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Article

Rapid detection of the CYP2A6*12 hybrid allele by Pyrosequencing technology.

BMC medical genetics - 24 Aug 2009

Koontz Deborah A, Huckins Jacqueline J, Spencer Antonina, Gallagher Margaret L

Abstract excerpt

BACKGROUND: Identification of CYP2A6 alleles associated with reduced enzyme activity is important in the study of inter-individual differences in drug metabolism. CYP2A6*12 is a hybrid allele that results from unequal crossover between CYP2A6 and CYP2A7 genes. The 5' regulatory region and exons 1-2 are derived from CYP2A7, and exons 3-9 are derived from CYP2A6. Conventional methods for detection of CYP2A6*12...

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Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2A6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P450 Family 2

Share to Gene Frequency

Share to Polymerase Chain Reaction

Share to Recombination, Genetic

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Source

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Identifiers

PMID: 19703308
DOI: 10.1186/1471-2350-10-80
PMCID: PMC2736934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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