Article
Pyrosequencing of clinically relevant polymorphisms.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005
Marsh Sharon, King Cristi R, Garsa Adam A, McLeod Howard L
Abstract excerpt
The data generated from the Human Genome Project has led to an explosion of technology for low-, medium-, and high-throughput genotyping methods. Pyrosequencing is a genotyping assay based on sequencing by synthesis. Short runs of sequence around each polymorphism are generated, allowing for internal controls for each sample. Pyrosequencing can also be used to identify tri-allelic, indel, and short-repeat...
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