Article

Cas9 targeted nanopore sequencing with enhanced variant calling improves <i>CYP2D6</i> - <i>CYP2D7</i> hybrid allele genotyping

2022-04-01

Abstract excerpt

CYP2D6 is one of the most challenging pharmacogenes to genotype due to the high similarity with its neighboring pseudogenes and the frequent occurrence of CYP2D6-CYP2D7 hybrids. Unfortunately, most current genotyping methods are therefore not able to correctly determine the complete CYP2D6-CYP2D7 sequence. Therefore, we developed a genotyping assay to generate complete allele-specific consensus sequences of comp...

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Literature Corpus work: 036fe7a4-c0ef-5113-b88a-69e146366512
DOI: 10.1101/2022.03.31.486504

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