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Article

Cas9 targeted nanopore sequencing with enhanced variant calling improves CYP2D6-CYP2D7 hybrid allele genotyping.

PLoS genetics - 1 Sept 2022

Rubben Kaat, Tilleman Laurentijn, Deserranno Koen, Tytgat Olivier, Deforce Dieter, Van Nieuwerburgh Filip

Abstract excerpt

CYP2D6 is a very important pharmacogene as it is responsible for the metabolization or bioactivation of 20 to 30% of the clinically used drugs. However, despite its relatively small length of only 4.4 kb, it is one of the most challenging pharmacogenes to genotype due to the high similarity with its neighboring pseudogenes and the frequent occurrence of CYP2D6-CYP2D7 hybrids. Unfortunately, most current...

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PMID: 36149915
DOI: 10.1371/journal.pgen.1010176
PMCID: PMC9534437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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