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Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics.

Respirology (Carlton, Vic.) - 1 Aug 2009

Asano Koichiro, Nakade Susumu, Shiomi Tetsuya, Nakajima Takeshi, Suzuki Yusuke, Fukunaga Koichi, Oguma Tsuyoshi, Sayama Koichi, Fujita Hirofumi, Tanigawara Yusuke, Ishizaka Akitoshi

Abstract excerpt

BACKGROUND AND OBJECTIVE: Wide inter-individual variability in therapeutic effects limits the efficacy of leukotriene (LT) receptor antagonists in the treatment of asthma. We have reported that genetic variability in the expression of LTC(4) synthase is associated with responsiveness to pranlukast in Japanese asthmatic patients. However, the effects of pharmacokinetic variability are less well known. This was an...

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PMID: 19703064
DOI: 10.1111/j.1440-1843.2009.01552.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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