Article
Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma.
Pharmacogenetics - 1 Oct 2002
Asano Koichiro, Shiomi Tetsuya, Hasegawa Naoki, Nakamura Hidetoshi, Kudo Hiroyasu, Matsuzaki Tatsu, Hakuno Haruhiko, Fukunaga Kouichi, Suzuki Yusuke, Kanazawa Minoru, Yamaguchi Kazuhiro
Abstract excerpt
CysLT(1) antagonists are effective for a subset of patients with asthma; however, there has been no good way to predict a given patient's response. We examined the interaction between the clinical response to a cysLT(1) antagonist, pranlukast, and DNA sequence variant A(-444)C in leukotriene C(4) synthase (LTC(4) S) gene in Japanese patients with moderate asthma. The frequency of LTC(4) S C(-444) allele was 21.6%...
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