Article
Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children.
Drug design, development and therapy - 1 Jan 2019
Li Qian, Wang Kai, Shi Hai-Yan, Wu Yue-E, Zhou Yue, Kan Min, Zheng Yi, Hao Guo-Xiang, Yang Xin-Mei, Yang Yi-Lei, Su Le-Qun, Wang Xiao-Ling, Jacqz-Aigrain Evelyne, Zhou Jun, Zhao Wei
Abstract excerpt
BACKGROUND: Montelukast, a potent oral selective leukotriene-receptor antagonist, inhibits the action of cysteinyl-leukotriene in patients with asthma. Although pharmacokinetic studies of montelukast have been reported in Caucasian adults and children, and showed large inter-individual variability on pharmacokinetics, none of these studies has been explored in Chinese children. Given the potential inter-ethnic...
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