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Article

A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy.

Therapeutic drug monitoring - 1 Dec 2018

Chen Yanan, Xu Shansen, Wang Zhanyou, Zhao Mingming, Wang Huanxin, Lu Tong, Zhao Limei

Abstract excerpt

BACKGROUND: The pharmacokinetics of lamotrigine (LTG) is complex and varies significantly among individuals, especially among children. Therefore, this study aimed to establish a population pharmacokinetic (PPK) model of LTG in Chinese children with epilepsy and to comprehensively evaluate the effects of genetic variations in drug-metabolizing enzymes, transporters, and a transcriptional regulator on LTG...

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Anticonvulsants
ATP-Binding Cassette Transporters
Drug Interactions
Epilepsy
Hepatocyte Nuclear Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inactivation, Metabolic

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Identifiers

PMID: 30169477
DOI: 10.1097/FTD.0000000000000563

Genes

ABCB1
ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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