Article
Pharmacokinetics of bosentan in routinely treated Japanese pediatric patients with pulmonary arterial hypertension.
Drug metabolism and pharmacokinetics - 1 Jun 2011
Taguchi Masato, Ichida Fukiko, Hirono Keiichi, Miyawaki Toshio, Yoshimura Naoki, Nakamura Tsuneyuki, Akita Chisato, Nakayama Tomotaka, Saji Tsutomu, Kato Yuya, Horiuchi Isao, Hashimoto Yukiya
Abstract excerpt
We evaluated the pharmacokinetics of routinely administered bosentan in 46 Japanese pediatric patients with pulmonary arterial hypertension. Plasma samples were taken twice at times corresponding to the peak and trough concentrations following repetitive oral administration. The population pharmacokinetic parameters of bosentan were estimated by use of the NONMEM program, in which a one-compartment model with...
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