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Article

Frequent <i>PIK3CA</i> gene amplification and its clinical significance in colorectal cancer

7 Jul 2009

Abstract excerpt

Using a DNA microarray approach to screen for gene copy number changes in 20 colorectal (CR) carcinoma samples and filtering for high-level DNA copy number changes, we detected an amplicon at 3q26 containing the PIK3CA gene. Fluorescence in situ hybridization was employed for evaluation of PIK3CA amplification on a progression CR tissue microarray containing 448 CR carcinomas, normal mucosa, and adenomas with...

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PMID: 19697359
DOI: 10.1002/path.2601

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