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Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies <i>PIK3R3</i> as a Potential Therapeutic Target in Epithelial Ovarian Cancer

15 Sept 2007

Abstract excerpt

PURPOSE: The phosphatidylinositol 3'-kinase (PI3K) family plays a key regulatory role in various cancer-associated signal transduction pathways. Here, we investigated the genomic alterations and gene expression of most known PI3K family members in human epithelial ovarian cancer. EXPERIMENTAL DESIGN: The DNA copy number of PI3K family genes was screened by a high-resolution array comparative genomic hybridization...

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PMID: 17875760
DOI: 10.1158/1078-0432.ccr-06-2660

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