Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

doi:10.1016/j.ccr.2005.05.014

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Article

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Cancer cell - 1 Jun 2005

Samuels Yardena, Diaz Luis A, Schmidt-Kittler Oleg, Cummins Jordan M, Delong Laura, Cheong Ian, Rago Carlo, Huso David L, Lengauer Christoph, Kinzler Kenneth W, Vogelstein Bert, Velculescu Victor E

Abstract excerpt

PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations have not been defined. To evaluate the consequences of PIK3CA alterations, the two most common mutations were inactivated by gene targeting in colorectal cancer (CRC) cells. Biochemical analyses of these cells showed that mutant PIK3CA selectively regulated the phosphorylation of AKT and the forkhead transcription factors...

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Identifiers

PMID: 15950905
DOI: 10.1016/j.ccr.2005.05.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.