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Article

PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma.

Oncotarget - 24 May 2016

Kim Hyo Song, Lee Seung Eun, Bae Yoon Sung, Kim Dae Joon, Lee Chang Geol, Hur Jin, Chung Hyunsoo, Park Jun Chul, Shin Sung Kwan, Lee Sang Kil, Lee Yong Chan, Kim Hye Ryun, Shim Young Mog, Jewell Susan S, Kim Hyunki, Choi Yoon La, Cho Byoung Chul

Abstract excerpt

To investigate the clinicopathologic characteristics and the prognostic impact of PIK3CA gene amplification in curatively resected esophageal squamous cell carcinoma (ESCC). Using 534 curatively resected ESCCs, the PIK3CA gene copy number was evaluated with fluorescent in situ hybridization. PIK3CA amplification was defined as PIK3CA/centromere 3 ratio is ≥ 2.0 or average number of PIK3CA signals/tumor cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27095573
DOI: 10.18632/oncotarget.8749
PMCID: PMC5058710

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AHR

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