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Article

Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer.

Chemico-biological interactions - 1 Nov 2020

Golla Jaya Prakash, Kandyliari Aikaterini, Tan Wan Ying, Chen Ying, Orlicky David J, Thompson David C, Shah Yatrik M, Vasiliou Vasilis

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis. Recently, we demonstrated that aldehyde dehydrogenase 1B1 (ALDH1B1) knockdown dramatically reduced colon tumor growth in a mouse xenograft model. The purpose of the present preliminary study is to examine the effect of loss of ALDH1B1...

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Identifiers

PMID: 33007288
DOI: 10.1016/j.cbi.2020.109274
PMCID: PMC9201852

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