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A new CRISPR-mediated Apc knockout allele leads to pyloric gland adenoma-like gastric polyps in mice with C57BL/6;FVB/N mixed background.

Animal models and experimental medicine - 1 May 2025

Uzun Sarp, Özcan Özge, Gök Ayşenur, Işık Aynur, Bakır Sinem, Günel-Özcan Ayşen, Onbaşılar İlyas, Akyol Aytekin

Abstract excerpt

Adenomatous polyposis coli (APC) mutations are the most frequently identified genetic alteration in sporadic colorectal cancer (CRC) cases, and a myriad of genetically engineered Apc-mutant CRC mouse models have been developed using various genetic manipulation techniques. The advent of the CRISPR/Cas9 system has revolutionized the field of genetic engineering and facilitated the development of new genetically...

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Identifiers

PMID: 39956793
DOI: 10.1002/ame2.70002
PMCID: PMC12107358

Genes

F8
APC

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