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Article

A target-selected <i>Apc</i> -mutant rat kindred enhances the modeling of familial human colon cancer

27 Feb 2007

Abstract excerpt

Progress toward the understanding and management of human colon cancer can be significantly advanced if appropriate experimental platforms become available. We have investigated whether a rat model carrying a knockout allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer of the human more closely than existing murine models. We have established a mutagen-induced...

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PMID: 17360473
DOI: 10.1073/pnas.0611690104

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