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Article

Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups.

PloS one - 20 Aug 2009

Dissanayeke Shobana Rebecca, Levin Samuel, Pienaar Sandra, Wood Kathryn, Eley Brian, Beatty David, Henderson Howard, Anderson Suzanne, Levin Michael

Abstract excerpt

Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene (TIRAP) have been associated with susceptibility and resistance to tuberculosis (TB) i...

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Source

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Identifiers

PMID: 19693265
DOI: 10.1371/journal.pone.0006698
PMCID: PMC2724706

Genes

TIRAP
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19693265-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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