Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations.

doi:10.1371/journal.pgen.1009392

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Article

Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations.

PLoS genetics - 1 Mar 2021

Quistrebert Jocelyn, Orlova Marianna, Kerner Gaspard, Ton Le Thi, Luong Nguyễn Trong, Danh Nguyễn Thanh, Vincent Quentin B, Jabot-Hanin Fabienne, Seeleuthner Yoann, Bustamante Jacinta, Boisson-Dupuis Stéphanie, Huong Nguyen Thu, Ba Nguyen Ngoc, Casanova Jean-Laurent, Delacourt Christophe, Hoal Eileen G, Alcaïs Alexandre, Thai Vu Hong, Thành Lai The, Abel Laurent, Schurr Erwin, Cobat Aurélie

Abstract excerpt

The natural history of tuberculosis (TB) is characterized by a large inter-individual outcome variability after exposure to Mycobacterium tuberculosis. Specifically, some highly exposed individuals remain resistant to M. tuberculosis infection, as inferred by tuberculin skin test (TST) or interferon-gamma release assays (IGRAs). We performed a genome-wide association study of resistance to M. tuberculosis...

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PMID: 33661925
DOI: 10.1371/journal.pgen.1009392
PMCID: PMC7963100

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