Article
Toll-like receptor 1(TLR1) Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children.
Tuberculosis (Edinburgh, Scotland) - 1 Mar 2015
Qi Hui, Sun Lin, Wu Xirong, Jin Yaqiong, Xiao Jing, Wang Shengfeng, Shen Chen, Chu Ping, Qi Zhan, Xu Fang, Guo Yajie, Jiao Weiwei, Tian Jianling, Shen Adong
Abstract excerpt
Toll-like receptor 1 (TLR1) recognizes lipopeptides with TLR2, and affects immune response to Mycobacterium tuberculosis infection. Here, we report results of the first case-control pediatric study of the TLR1 single-nucleotide polymorphisms and susceptibility to tuberculosis (TB). A pediatric case-control study enrolled 340 TB patients and 366 healthy controls, all Han Chinese from North China. Significant...
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