Article
A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis.
American journal of respiratory and critical care medicine - 15 Aug 2017
Shah Javeed A, Musvosvi Munyaradzi, Shey Muki, Horne David J, Wells Richard D, Peterson Glenna J, Cox Jeffery S, Daya Michelle, Hoal Eileen G, Lin Lin, Gottardo Raphael, Hanekom Willem A, Scriba Thomas J, Hatherill Mark, Hawn Thomas R
Abstract excerpt
RATIONALE: The molecular mechanisms that regulate tuberculosis susceptibility and bacillus Calmette-Guérin (BCG)-induced immunity are mostly unknown. However, induction of the adaptive immune response is a critical step in host control of Mycobacterium tuberculosis. Toll-interacting protein (TOLLIP) is a ubiquitin-binding protein that regulates innate immune responses, including Toll-like receptor signaling,...
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