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Article

A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis.

The Journal of infectious diseases - 15 Oct 2006

Hawn Thomas R, Dunstan Sarah J, Thwaites Guy E, Simmons Cameron P, Thuong Nguyen Thuong, Lan Nguyen Thi Ngoc, Quy Hoang Thi, Chau Tran Thi Hong, Hieu Nguyen T, Rodrigues Stephanie, Janer Marta, Zhao Lue Ping, Hien Tran Tinh, Farrar Jeremy J, Aderem Alan

Abstract excerpt

BACKGROUND: Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16991088
DOI: 10.1086/507907
PMCID: PMC4333200

Genes

TIRAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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