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Article

Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis.

The Journal of infectious diseases - 15 Feb 2012

Horne David J, Randhawa April K, Chau Tran T H, Bang Nguyen D, Yen Nguyen T B, Farrar Jeremy J, Dunstan Sarah J, Hawn Thomas R

Abstract excerpt

BACKGROUND: Tuberculosis has been associated with genetic variation in host immunity. We hypothesized that single-nucleotide polymorphisms (SNPs) in SIGIRR, a negative regulator of Toll-like receptor/IL-1R signaling, are associated with susceptibility to tuberculosis. METHODS: We used a case-population study design in Vietnam with cases that had either tuberculous meningitis or pulmonary tuberculosis. We...

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Source

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Identifiers

PMID: 22223854
DOI: 10.1093/infdis/jir785
PMCID: PMC3266131

Genes

SIGIRR
PKP3
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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