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Article

Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.

Circulation - 1 Sept 2009

Belin de Chantemèle Eric J, Muta Kenjiro, Mintz James, Tremblay Michel L, Marrero Mario B, Fulton David J, Stepp David W

Abstract excerpt

BACKGROUND: Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin. Protein tyrosine phosphatase 1B (PTP1B), a major new pharmaceutical target in the treatment of obesity and type II diabetes mellitus, constrains the metabolic actions of leptin, but the extent to which PTP1B regulates its cardiovascular effects is unclear. This study examined the hypothesis that PTP1B is a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Receptors, Adrenergic, alpha-1

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Source

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Identifiers

PMID: 19687357
DOI: 10.1161/CIRCULATIONAHA.109.853077
PMCID: PMC2736363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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