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Article

Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice.

Cardiovascular research - 1 Aug 2016

Gogiraju Rajinikanth, Schroeter Marco R, Bochenek Magdalena L, Hubert Astrid, Münzel Thomas, Hasenfuss Gerd, Schäfer Katrin

Abstract excerpt

AIMS: Cardiac angiogenesis is an important determinant of heart failure. We examined the hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular endothelial growth factor (VEGF) receptor-2 activation, is causally involved in the cardiac microvasculature rarefaction during hypertrophy and that deletion of PTP1B in endothelial cells prevents the development of heart failure. METHODS...

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PMID: 27207947
DOI: 10.1093/cvr/cvw101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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