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Article

Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2010

Payne Gregory A, Borbouse Léna, Kumar Sajel, Neeb Zachary, Alloosh Mouhamad, Sturek Michael, Tune Johnathan D

Abstract excerpt

OBJECTIVE: Factors released by perivascular adipose tissue (PVAT) disrupt coronary endothelial function via phosphorylation of endothelial NO synthase by protein kinase C (PKC)-beta. However, our understanding of how PVAT potentially contributes to coronary disease as a complication of obesity/metabolic syndrome (MetS) remains limited. The current study investigated whether PVAT-derived leptin impairs coronary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20576943
DOI: 10.1161/ATVBAHA.110.210070
PMCID: PMC2924445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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