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Article

Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2011

Harlan Shannon M, Morgan Donald A, Dellsperger David J, Myers Martin G, Mark Allyn L, Rahmouni Kamal

Abstract excerpt

Leptin acts in the brain to regulate food intake and energy expenditure. Leptin also increases renal sympathetic nerve activity and arterial pressure. The divergent signaling capacities of the leptin receptor (ObRb) mediate the stimulation of various intracellular pathways that are important for leptin control of physiological processes. We evaluated the cardiovascular and sympathetic consequences of disrupting...

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Identifiers

PMID: 21263121
DOI: 10.1161/HYPERTENSIONAHA.110.166538
PMCID: PMC3072273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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