Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leptin, Obesity, and Hypertension: A Review of Pathogenetic Mechanisms.

Metabolic syndrome and related disorders - 1 Nov 2020

Lu Song Chi, Akanji Abayomi O

Abstract excerpt

The adipokine leptin is expressed at higher concentrations in obese subjects, who also incidentally have a higher prevalence of hypertension. The pathogenesis of this obesity-related hypertension is controversial and is believed to be related to many factors including increased sympathetic activity, abnormalities of the renin-angiotensin system, sodium retention, and an endotheliopathy acting independently or in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypertension
Share to Hypothalamus
Share to Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leptin

Share to Obesity

Share to Pro-Opiomelanocortin

Share to Spinal Cord

Share to Sympathetic Nervous System

Source

Identifiers

PMID: 32876506
DOI: 10.1089/met.2020.0065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leptin, Obesity, and Hypertension: A Review of Pathogenetic Mechanisms.PMID 32876506Read ↗

Leptin Signaling in the Central Nervous System and the PeripherySemantic proximity Read ↗

Leptin-Aldosterone-Neprilysin Axis: Identification of Its Distinctive Role in the Pathogenesis of the Three Phenotypes of Heart Failure in People With Obesity.Semantic proximity Read ↗

Human leptin: an adipocyte hormone with weight-regulatory and endocrine functions.Semantic proximity Read ↗

New perspectives on the origin of hypertension; the role of the hypothalamic melanocortin systemSemantic proximity Read ↗

Structure, production and signaling of leptin.Semantic proximity Read ↗

Leptin mediates the increase in blood pressure associated with obesity.Semantic proximity Read ↗

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated DefectsSemantic proximity Read ↗

Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population.Semantic proximity Read ↗

Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor.Semantic proximity Read ↗

Melanocortin signalling and the regulation of blood pressure in human obesity.Semantic proximity Read ↗

Obesity-Related Hypertension: An Emerging Clinical Phenotype.Semantic proximity Read ↗

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated DefectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.