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Article

Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1.

Cancer research - 15 Feb 1991

Bale A E, Norton J A, Wong E L, Fryburg J S, Maton P N, Oldfield E H, Streeten E, Aurbach G D, Brandi M L, Friedman E

Abstract excerpt

Familial multiple endocrine neoplasia type 1 (FMEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, pancreatic islets, and anterior pituitary. The gene for this disease maps to chromosome 11q12-11q13, and allelic loss in this region has been shown in both spo...

Topics

Adenoma, Islet Cell
Alleles
Carcinoma, Bronchogenic
Chromosomes, Human, Pair 11
Genes, Tumor Suppressor
Humans
Multiple Endocrine Neoplasia
Pancreatic Neoplasms
Pituitary Neoplasms
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1671755

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1671755-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1.PMID 1671755Read ↗

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.Semantic proximity Read ↗

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.Semantic proximity Read ↗

Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.Semantic proximity Read ↗

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.Semantic proximity Read ↗

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.Semantic proximity Read ↗

Deletion of chromosome 1, but not mutation of MEN-1, predicts prognosis in sporadic pancreatic endocrine tumors.Semantic proximity Read ↗

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.Semantic proximity Read ↗

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Allele loss on chromosome 11 in a pituitary tumor from a patient with multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Loss of heterozygosity on chromosome arm 11q in lung carcinoids.Semantic proximity Read ↗

Analysis of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

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