Article
Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors.
Cancer research - 15 Aug 1998
Chung D C, Brown S B, Graeme-Cook F, Tillotson L G, Warshaw A L, Jensen R T, Arnold A
Abstract excerpt
Only two tumor suppressor gene loci, one on 3p25 and the MEN1 gene on 11q13, have thus far been implicated in the pathogenesis of sporadic human pancreatic endocrine tumors (PETs). A genome-wide allelotyping study of 28 human PETs was undertaken to identify other potential tumor suppressor gene loci. In addition to those on chromosomes 3p and 11q, frequent allelic deletions were identified on 3q (32%), 11p (36%),...
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