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Article

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.

Cancer research - 15 Nov 1996

Lubensky I A, Debelenko L V, Zhuang Z, Emmert-Buck M R, Dong Q, Chandrasekharappa S, Guru S C, Manickam P, Olufemi S E, Marx S J, Spiegel A M, Collins F S, Liotta L A

Abstract excerpt

Familial multiple endocrine neoplasia type 1 is an autosomal dominant hereditary disorder characterized by multiple parathyroid, pancreatic, duodenal, and pituitary tumors. The parathyroid tumors may arise as diffuse areas of hyperplasia, whereas the pancreatic and duodenal tumors usually form as discrete nodules. Except for a single report, tumor loss of heterozygosity (LOH) mapping of the putative MEN1...

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Source

Identifiers

PMID: 8912868

Genes

MEN1
PYGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.PMID 8912868Read ↗

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.Semantic proximity Read ↗

Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.Semantic proximity Read ↗

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.Semantic proximity Read ↗

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.Semantic proximity Read ↗

Multiple endocrine neoplasia type 1 (MEN1): LOH studies in a affected family and in sporadic cases.Semantic proximity Read ↗

Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region.Semantic proximity Read ↗

Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Identification and characterization of the multiple endocrine neoplasia type 1 (MEN1) gene.Semantic proximity Read ↗

Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism.Semantic proximity Read ↗

Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis.Semantic proximity Read ↗

Multiple Endocrine Neoplasia Type 1 (MEN1): Loss of One MEN1 Allele in Tumors and Monohormonal Endocrine Cell Clusters But Not in Islet Hyperplasia of the PancreasSemantic proximity Read ↗

Putative parathyroid tumor suppressor on 1p: independent molecular mechanisms of tumorigenesis from 11q allelic loss.Semantic proximity Read ↗

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