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Article

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.

Cancer research - 1 Jun 1997

Debelenko L V, Zhuang Z, Emmert-Buck M R, Chandrasekharappa S C, Manickam P, Guru S C, Marx S J, Skarulis M C, Spiegel A M, Collins F S, Jensen R T, Liotta L A, Lubensky I A

Abstract excerpt

Endocrine tumors (ETs) of pancreas and duodenum occur sporadically and as a part of multiple endocrine neoplasia type 1 (MEN1). The MEN1 tumor suppressor gene has been localized to chromosome 11q13 by linkage analysis but has not yet isolated. Previous allelic deletion studies in enteropancreatic ETs suggested MEN1 gene involvement in tumorigenesis of familial pancreatic ETs (nongastrinomas) and sporadic...

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PMID: 9187127

Genes

MEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.PMID 9187127Read ↗

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.Semantic proximity Read ↗

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.Semantic proximity Read ↗

Deletion of chromosome 1, but not mutation of MEN-1, predicts prognosis in sporadic pancreatic endocrine tumors.Semantic proximity Read ↗

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.Semantic proximity Read ↗

Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.Semantic proximity Read ↗

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.Semantic proximity Read ↗

Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.Semantic proximity Read ↗

Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors.Semantic proximity Read ↗

Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesisSemantic proximity Read ↗

Multiple Endocrine Neoplasia Type 1 (MEN1): Loss of One MEN1 Allele in Tumors and Monohormonal Endocrine Cell Clusters But Not in Islet Hyperplasia of the PancreasSemantic proximity Read ↗

Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN 1-associated pancreatic endocrine tumorsSemantic proximity Read ↗

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