Article
Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13.
Journal of internal medicine - 1 Sept 1995
Teh B T, Cardinal J, Shepherd J, Hayward N K, Weber G, Cameron D, Larsson C
Abstract excerpt
Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition,...
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