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Article

Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc.

Journal of bacteriology - 1 Oct 2009

Serafini Agnese, Boldrin Francesca, Palù Giorgio, Manganelli Riccardo

Abstract excerpt

Recently, a novel type of secretory pathway, type VII secretion systems (T7SSs), has been characterized in mycobacteria. The chromosomes of Mycobacterium tuberculosis and Mycobacterium bovis encode five T7SSs (ESX-1 to ESX-5). The best characterized of them, ESX-1, is involved in host-pathogen interactions, and its deletion is one of the main causes of M. bovis BCG attenuation. Another T7SS, ESX-3, has been...

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Identifiers

PMID: 19684129
DOI: 10.1128/JB.00756-09
PMCID: PMC2753049

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