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Article

<i>Mycobacterium tuberculosis</i> evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system

2020-07-27

Abstract excerpt

Cell-intrinsic immune mechanisms control intracellular pathogens that infect eukaryotes. The intracellular pathogen Mycobacterium tuberculosis ( Mtb ) evolved to withstand cell-autonomous immunity to cause persistent infections and disease. A potent inducer of cell-autonomous immunity is the lymphocyte-derived cytokine IFNγ. While the production of IFNγ by T cells is essential to protect against Mtb , it is not...

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Identifiers and source

Literature Corpus work
8dc39228-af59-51f6-af32-0923e8edd5e3
DOI
10.1101/2020.07.27.223362
Open publication

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<i>Mycobacterium tuberculosis</i> evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion systemDOI 10.1101/2020.07.27.223362
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