Article

ESX-5 Deletions in <i>Mycobacterium tuberculosis</i> Alter Macrophage Cytokine Signaling and Bacterial Heavy Metal Response

2025-10-02

Abstract excerpt

<h4>Summary</h4> The ESX-5 secretion system is critical for Mycobacterium tuberculosis (Mtb) viability and putatively linked to pathogenesis, but a functional understanding of how it interacts with the host is unknown. ESX-5 is encoded at a single genomic locus with small, paralogous, secreted targets (ESX-5a, 5b, 5c) spaced throughout the genome. To examine host-pathogen interactions of these putative virulence...

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Literature Corpus work: 6a51f5e2-1174-519d-95b8-3e4d2525aee6
DOI: 10.1101/2025.09.30.679525

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