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Article

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016

Tufariello JoAnn M, Chapman Jessica R, Kerantzas Christopher A, Wong Ka-Wing, Vilchèze Catherine, Jones Christopher M, Cole Laura E, Tinaztepe Emir, Thompson Victor, Fenyö David, Niederweis Michael, Ueberheide Beatrix, Philips Jennifer A, Jacobs William R

Abstract excerpt

Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS), designated ESX-1-ESX-5, that are critical for growth and pathogenesis. The best characterized is ESX-1, which profoundly impacts host cell interactions. In contrast, the ESX-3 T7SS is implicated in metal homeostasis, but efforts to define its function have been limited by an inability to recover deletion mutants. We overcame this...

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PMID: 26729876
DOI: 10.1073/pnas.1523321113
PMCID: PMC4725510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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