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Article

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009

Siegrist M Sloan, Unnikrishnan Meera, McConnell Matthew J, Borowsky Mark, Cheng Tan-Yun, Siddiqi Noman, Fortune Sarah M, Moody D Branch, Rubin Eric J

Abstract excerpt

The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear. Esx-3, a paralogous system present in all mycobacterial species, is required for growth in vitro. Here, we demonstrate that mycobacteria lacking Esx-3 are defective in acquiring iron. To...

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Identifiers

PMID: 19846780
DOI: 10.1073/pnas.0900589106
PMCID: PMC2774023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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