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Article

Silencing Mycobacterium smegmatis by using tetracycline repressors.

Journal of bacteriology - 1 Jul 2007

Guo Xinzheng V, Monteleone Mercedes, Klotzsche Marcus, Kamionka Annette, Hillen Wolfgang, Braunstein Miriam, Ehrt Sabine, Schnappinger Dirk

Abstract excerpt

Many processes that are essential for mycobacterial growth are poorly understood. To facilitate genetic analyses of such processes in mycobacteria, we and others have developed regulated expression systems that are repressed by a tetracycline repressor (TetR) and induced with tetracyclines, permitting the construction of conditional mutants of essential genes. A disadvantage of these systems is that tetracyclines...

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Identifiers

PMID: 17483222
DOI: 10.1128/JB.00216-07
PMCID: PMC1913471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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