Article
A heterodimer of EsxA and EsxB is involved in sporulation and is secreted by a type VII secretion system in Streptomyces coelicolor.
Microbiology (Reading, England) - 1 Jun 2010
Akpe San Roman Sandra, Facey Paul D, Fernandez-Martinez Lorena, Rodriguez Caridad, Vallin Carlos, Del Sol Ricardo, Dyson Paul
Abstract excerpt
An esx locus, related to the multiple esx loci of Mycobacterium tuberculosis, is conserved in all sequenced Streptomyces genomes, where it is associated with the developmental regulatory gene bldB. Here we demonstrate that the esxBA operon, comprising part of the locus, has a novel morphogenetic function in the model species Streptomyces coelicolor. This operon encodes two proteins belonging to the WXG-100...
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