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Article

An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology.

Scientific reports - 24 Apr 2017

Clemmensen Helena Strand, Knudsen Niels Peter Hell, Rasmussen Erik Michael, Winkler Jessica, Rosenkrands Ida, Ahmad Ahmad, Lillebaek Troels, Sherman David R, Andersen Peter Lawætz, Aagaard Claus

Abstract excerpt

Although Mycobacterium tuberculosis (M.tb) DK9897 is an attenuated strain, it was isolated from a patient with extrapulmonary tuberculosis and vaccination with a subunit vaccine (H56) induced poor protection against it. Both attenuation and lack of protection are because M.tb DK9897 cannot secrete the EsxA virulence factor nor induce a host response against it. Genome sequencing identified a frameshift mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28436493
DOI: 10.1038/srep46666
PMCID: PMC5402389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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