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Article

Performance-related increases in hippocampal N-acetylaspartate (NAA) induced by spatial navigation training are restricted to BDNF Val homozygotes.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jun 2011

Lövdén Martin, Schaefer Sabine, Noack Hannes, Kanowski Martin, Kaufmann Jörn, Tempelmann Claus, Bodammer Nils Christian, Kühn Simone, Heinze Hans-Jochen, Lindenberger Ulman, Düzel Emrah, Bäckman Lars

Abstract excerpt

Recent evidence indicates experience-dependent brain volume changes in humans, but the functional and histological nature of such changes is unknown. Here, we report that adult men performing a cognitively demanding spatial navigation task every other day over 4 months display increases in hippocampal N-acetylaspartate (NAA) as measured with magnetic resonance spectroscopy. Unlike measures of brain volume,...

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Source

Identifiers

PMID: 21071619
DOI: 10.1093/cercor/bhq230

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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